Biomarker studies is the latest focus of the pharmaceutical and biotech worlds. So much might be learned by looking at how drugs and natural products/ingredients affect the body. Per Wiki, a biomarker is explained as: “in medicine, a biomarker can be a substance that is introduced into an organism as a means to examine organ function or other aspects of health. For example, rubidium chloride is used as a radioactive isotope to evaluate perfusion of heart muscle.
It can also be a substance whose detection indicates a particular disease state, for example, the presence of an antibody may indicate an infection (see biomarker (medicine) ). More specifically, a biomarker indicates a change in expression or state of a protein that correlates with the risk or progression of a disease, or with the susceptibility of the disease to a given treatment. Once a proposed biomarker has been validated, it can be used to diagnose disease risk, presence of disease in an individual, or to tailor treatments for the disease in an individual (choices of drug treatment or administration regimes). In evaluating potential drug therapies, a biomarker may be used as a surrogate for a natural endpoint such as survival or irreversible morbidity. If a treatment alters the biomarker, which has a direct connection to improved health, the biomarker serves as a surrogate endpoint for evaluating clinical benefit.”
A Phase 1 study published in Cancer Epidemoil Biomarkers Prevention in 2007 studied resveratrol in healthy volunteers. Phase 1 trials are typically the first trials in which a drug is tested in a human volunteer. The volunteer can be healthy or have the disease that is being studied. The hypothesis of this study “was tested that, in healthy humans, p.o. administration of resveratrol is safe and results in measurable plasma levels of resveratrol.” Resveratrol was provided to a small sample size of 10 healthy volunteers in a 0.5, 1, 2.5, or5 g dose format.
“The results presented here intimate that consumption of high-dose resveratrol might be insufficient to elicit systemic levels commensurate with cancer chemopreventive efficacy. However, the high systemic levels of resveratrol conjugate metabolites suggest that their cancer chemopreventive properties warrant investigation.”
Here is a website that list some studies of resveratrol: http://www.anyvitamins.com/resveratrol-references.htm . Unfortunately, it only lists the studies with no results.
There currently eight registered on-going trials:
New York’s Mount Sinai School of Medicine’s Alzheimer’s Disease Research Center is currently recruiting subjects for their study of resveratrol and alzheimer http://www.delay-ad.org/trials/resveratrol . The University of California is recruiting subjects to perform clinical trials ”to define the actions of resveratrol on the Wnt signaling pathway in a clinical trial in which patients with colon cancer will receive treatment with resveratrol and correlative laboratory studies will examine its effects directly on colon cancer and normal colonic mucosa. These studies will provide data on the mechanisms of resveratrol action and provide a foundation for future prevention trials, correlative studies and therapeutic clinical research with this agent.” http://clinicaltrials.gov/ct2/show/NCT00256334?term=resveratrol&rank=2
For a complete list of the eight trials registered under the government, refer to this link: http://clinicaltrials.gov/ct2/results?term=resveratrol .
Based on researching more about Resveatrol, stay clear of claims of free trials of the product especially if seen on 60 Minutes or Oprah. I read many consumers who signed up for the “free offer” only to be charged large amounts and no one to contact to get a refund. I guess it’s marketed under Resveratrol Ultra and under SWM Labs. Read that small print before buying for all the details such as what others wrote as a scam. You can buy Biotivia brand for $24 for a 240 mb bottle (250 mg). I only noticed headaches when I took resveratrol but can’t say for sure it was attributed to the product. Biomarker study is the latest focus of the pharmaceutical and biotech worlds. So much might be learned by looking at how drugs and natural products/ingredients affect the body. Per Wiki, a biomarker is explained as: “in medicine, a biomarker can be a substance that is introduced into an organism as a means to examine organ function or other aspects of health. For example, rubidium chloride is used as a radioactive isotope to evaluate perfusion of heart muscle .
It can also be a substance whose detection indicates a particular disease state, for example, the presence of an antibody may indicate an infection (see biomarker (medicine) ). More specifically, a biomarker indicates a change in expression or state of a protein that correlates with the risk or progression of a disease, or with the susceptibility of the disease to a given treatment. Once a proposed biomarker has been validated, it can be used to diagnose disease risk, presence of disease in an individual, or to tailor treatments for the disease in an individual (choices of drug treatment or administration regimes). In evaluating potential drug therapies, a biomarker may be used as a surrogate for a natural endpoint such as survival or irreversible morbidity. If a treatment alters the biomarker, which has a direct connection to improved health, the biomarker serves as a surrogate endpoint for evaluating clinical benefit.”
A Phase 1 study published in Cancer Epidemoil Biomarkers Prevention in 2007 studied resveratrol in healthy volunteers. Phase 1 trials are typically the first trials in which a drug is tested in a human volunteer. The volunteer can be healthy or have the disease that is being studied. The hypothesis of this study “was tested that, in healthy humans, p.o. administration of resveratrol is safe and results in measurable plasma levels of resveratrol.” Resveratrol was provided to a small sample size of 10 healthy volunteers in a 0.5, 1, 2.5, or5 g dose format.
“The results presented here intimate that consumption of high-dose resveratrol might be insufficient to elicit systemic levels commensurate with cancer chemopreventive efficacy. However, the high systemic levels of resveratrol conjugate metabolites suggest that their cancer chemopreventive properties warrant investigation.”
Here is a website that list some studies of resveratrol: http://www.anyvitamins.com/resveratrol-references.htm . Unfortunately, it only lists the studies with no results.
There currently eight registered on-going trials:
New York’s Mount Sinai School of Medicine’s Alzheimer’s Disease Research Center is currently recruiting subjects for their study of resveratrol and alzheimer http://www.delay-ad.org/trials/resveratrol . The University of California is recruiting subjects to perform clinical trials ”to define the actions of resveratrol on the Wnt signaling pathway in a clinical trial in which patients with colon cancer will receive treatment with resveratrol and correlative laboratory studies will examine its effects directly on colon cancer and normal colonic mucosa. These studies will provide data on the mechanisms of resveratrol action and provide a foundation for future prevention trials, correlative studies and therapeutic clinical research with this agent.” http://clinicaltrials.gov/ct2/show/NCT00256334?term=resveratrol&rank=2
For a complete list of the eight trials registered under the government, refer to this link: http://clinicaltrials.gov/ct2/results?term=resveratrol .
Based on researching more about Resveatrol, stay clear of claims of free trials of the product especially if seen on 60 Minutes or Oprah. I read many consumers who signed up for the “free offer” only to be charged large amounts and no one to contact to get a refund. I guess it’s marketed under Resveratrol Ultra and under SWM Labs. Read that small print before buying for all the details such as what others wrote as a scam. You can buy Biotivia brand for $24 for a 240 mb bottle (250 mg). I only noticed headaches when I took resveratrol but can’t say for sure it was attributed to the product.
There are many types of products on Amazon:
Showing posts with label Resveratol. Show all posts
Showing posts with label Resveratol. Show all posts
Good Foods for the Skin
Different websites are touting the benefits of eating right on your skin to prevent wrinkles and retain that youthful glow. I have a friend who at 50, looked AMAZING and actually looked like she was 40. She credited this youthful, wrinkless, glowing complexion to eating right, drinking plenty of water and taking many supplements. Either her genes were very good and/or the lifestyle was working because she looked incredible.
Lycopene from processed tomatoes provides a great source of an anti-oxidant and also helps to ward off cancerous cell formations. Lycopene, in high doses, flush out free radicals. Since lycopene is not made in the body, we require products such as tomatoes to acquire it.
“Researchers introduced Lycopene into pre-existing cancer cell cultures and the Lycopene prevented the continued growth of these cultures. This is pretty powerful evidence that the health benefits of eating a tomato are really quite phenomenal. It takes as little as 540 milliliters of liquid tomato product to get the full benefits of Lycopene. This means that a daily glass of tomato juice has the potential to keep a person healthy for life.”
Oysters provides zinc which provides that nice little feature of repairing and renewing our skin called collagen. As we age, we lose that ability.
Blueberries prevent cell damage by also being a source of an anti-oxidant. In 2004, a team led by a USDA chemist found that this natural anti-oxidant may lower blood levels of LDL which is the “bad” cholesterol and triglycerides. The pterostilbene in blueberries is similar to the chemical Resveratrol found in grapes. Another claim for blueberries as an antioxidant is the benefit towards slowing down visual loss due to the extract from blueberries. It’s called anthocyanosides and has been found in clinical studies to slow down visual loss.
”A recent study was done in a Boston laboratory by putting one group of young rats on a blueberry-rich diet and another on regular chow. Then the scientist exposed both groups to 48 hours of concentrated oxygen, stirring up in two days the amount of free radical damage that normally takes 20 rat months, or 75 humans to accumulate. Brain cells in the chow group became less responsive to neurotransmitters associated with short-term memory. The brains of the blueberry stuffed rats did not change. He also found that the fruit prevented the kind of short-term memory loss that comes with aging. Blueberries actually stave off declines in brain cell’s ability to send messages to one another.”
Dark chocolate has many benefits to include providing yet another anti-oxidant source. It increases blood flow to the skin which rehydrates the skin and provides additional sun protection.
Walnuts provides omega-3 and vitamin E which is a natural way to ward off psoriasis and eczema. Omega-3 fatty acids also provide benefits ranging from better mental functioning to cardiovascular protection to an anti-inflammatory benefits in asthma.
Lycopene from processed tomatoes provides a great source of an anti-oxidant and also helps to ward off cancerous cell formations. Lycopene, in high doses, flush out free radicals. Since lycopene is not made in the body, we require products such as tomatoes to acquire it.
“Researchers introduced Lycopene into pre-existing cancer cell cultures and the Lycopene prevented the continued growth of these cultures. This is pretty powerful evidence that the health benefits of eating a tomato are really quite phenomenal. It takes as little as 540 milliliters of liquid tomato product to get the full benefits of Lycopene. This means that a daily glass of tomato juice has the potential to keep a person healthy for life.”
Oysters provides zinc which provides that nice little feature of repairing and renewing our skin called collagen. As we age, we lose that ability.
Blueberries prevent cell damage by also being a source of an anti-oxidant. In 2004, a team led by a USDA chemist found that this natural anti-oxidant may lower blood levels of LDL which is the “bad” cholesterol and triglycerides. The pterostilbene in blueberries is similar to the chemical Resveratrol found in grapes. Another claim for blueberries as an antioxidant is the benefit towards slowing down visual loss due to the extract from blueberries. It’s called anthocyanosides and has been found in clinical studies to slow down visual loss.
”A recent study was done in a Boston laboratory by putting one group of young rats on a blueberry-rich diet and another on regular chow. Then the scientist exposed both groups to 48 hours of concentrated oxygen, stirring up in two days the amount of free radical damage that normally takes 20 rat months, or 75 humans to accumulate. Brain cells in the chow group became less responsive to neurotransmitters associated with short-term memory. The brains of the blueberry stuffed rats did not change. He also found that the fruit prevented the kind of short-term memory loss that comes with aging. Blueberries actually stave off declines in brain cell’s ability to send messages to one another.”
Dark chocolate has many benefits to include providing yet another anti-oxidant source. It increases blood flow to the skin which rehydrates the skin and provides additional sun protection.
Walnuts provides omega-3 and vitamin E which is a natural way to ward off psoriasis and eczema. Omega-3 fatty acids also provide benefits ranging from better mental functioning to cardiovascular protection to an anti-inflammatory benefits in asthma.
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